Biosynthesis of Cephalosporin C: I. Factors Affecting the Fermentation.

نویسندگان

  • J L Ott
  • C W Godzeski
  • D Pavey
  • J D Farran
  • D R Horton
چکیده

A series of complex and synthetic media have been developed that are suitable for the production of cephalosporin C and cephalosporin N by a mutant strain of Cephalosporium (C.M.I. 49,137). dl-Methionine increased the yield of both antibiotics, with more effect on cephalosporin N. l-Cystine had a greater enhancing effect on formation of cephalosporin C than on formation of cephalosporin N in synthetic media; serine increased yields of cephalosporin C under certain conditions. Disaccharides or polysaccharides appeared to be the best source for carbohydrates. No evidence was found for precursor action such as is found in penicillin fermentations. The ability of resting cells to produce antibiotic was demonstrated.

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OTT, J. L. (Eli Lilly and Co., Indianapolis, Ind.), C. W. GODZESKI, D. PAVEY, J. D. FARRAN, AND D. R. HORTON. Biosynthesis of cephalosporin C. I. Factors affecting the fermentation. Appl. Microbiol. 10:515-523. 1962.-A series of complex and synthetic media have been developed that are suitable for the production of cephalosporin C and cephalosporin N by a mutant strain of Cephalosporium (C.M.I....

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عنوان ژورنال:
  • Applied microbiology

دوره 10 6  شماره 

صفحات  -

تاریخ انتشار 1962